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Fluorine atom, removal from fluoroacetates

Fluoroacetate causes inhibition of aconitase, an enzyme in the tricarboxylic acid cycle. This is due to the formation of fluorocitrate, which binds to aconitase and inhibits the enzyme. This is because the fluorine atom cannot be removed from the fluorocitrate unlike the hydrogen atom in the normal substrate, citrate. The result is complete blockade of the cycle and this means tissues become starved of ATP and other vital metabolic intermediates. This causes adverse effects in the heart as the organ is particularly sensitive to deficiency of ATP. [Pg.434]

See also in sourсe #XX -- [ Pg.12 , Pg.17 , Pg.115 , Pg.147 , Pg.148 , Pg.160 ]

See also in sourсe #XX -- [ Pg.12 , Pg.17 , Pg.115 , Pg.147 , Pg.148 , Pg.160 ]

See also in sourсe #XX -- [ Pg.12 , Pg.17 , Pg.115 , Pg.147 , Pg.148 , Pg.160 ]



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Atom removal

Fluorine atoms

Fluoroacetate

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