Fluorine as a Bioisostere

The use of fluorine to modulate properties including potency, selectivity, pharmacokinetics, and toxicity has have been highlighted. Fluorine has also been suggested as a potential bioisosteric replacement for a number of functional groups, examples of which are presented in the final section. 

Skidmore, V. Soleil, K. J. Smith, S. Stanway, G. Stemp, A. Stuart, S. Sweitzer, P. Theobald, D. Vesey, D. S. Walter, J. Ward, and G. Wayne, Bioorg. Med. Chem. Lett., 2008,18, 1022. 

Miyazoe, T. Tsujita, M. Hirayama, S. Ozaki, T. Tani, Y. Ishii, H. Ohta, and O. Okamoto, Bioorg. Med. Chem. Lett., 2009,19, 3627. 

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