Fluorination Fluoro- 3-alanine

The substitution of a hydrogen for a fluorine-18 has been widely used. Direct radiofluorination of l-DOPA [68] (3,4-dihydroxyphenyl-L-alanine) yields the three possible stereoisomers [2- F], [5- F] and [6- F]fluoro-L-DOPA in 12,1.7 and 21 % yields respectively (Scheme 6). A complex HPLC purification leads to the preferred [6- F]fluoro-L-DOPA in 3 % radiochemical yield. 

Adamantanc is fluorinated by trifluoromethyl hypofluorite with the highest yields being obtained in the presence of radical inhibitors (see Vol. ElOa. p 270ff). This is in sharp contrast to reported photo-induced monofluorinaiions of cyclohexane and amino acids with tri-fluoroniethyl hypofluorite, which do not proceed in the absence of light.An example is the fluorination of o-alanine to give 3-fluoro-D-alunine (3). "... 

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