Fluorination ethyl-2-methyl-3-oxobutanoate

Cas/liquid reaction 5 [CL 5] Fluorination of ethyl 2-methyl-3-oxobutanoate (ethyl-2-methylacetoacetate) [16]... 

No metalation is required for the / -fluorination of a-oxo esters.150 Ethyl 3-methyl-2-oxo-butanoate and 3-methyl-2-oxopentanoic acid give the corresponding /f-fluoro derivatives 30 a and 30 b, respectively, in quantitative yield on reaction with A-fluorobis(trifluoromethylsul-fonyl)amine (Id). 3-Fluoro-2-oxobutanoic acid (30c) is exclusively formed by treating 2-oxobutanoic acid with an equimolar amount of reagent Id.150... 

This microflow processing was also demonstrated using other P-keto esters such as ethyl 2-chloro-3-oxobutanoate [309,273] or ethyl 2-methyl-3-oxobutanoate [273]. Five-and six-ring P-ketoester derivatives such as 3-acetyl-3,4,5-trihydrofuran-2-one (1) [273], 2-acetyl cyclohexanone [273] and ethyl 2-oxocydohexane carboxylate (2) [273] were directly fluorinated as well. 

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See also in sourсe #XX -- [ ]

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