Fluorinated phosphatidylcholines

Tan H, Liu 1, Li 1, Jiang X, Xie X, Zhong Y, et al. Synthesis and hemocompatibility of biomembrane mimicing poly(carbonate urethane)s containing fluorinated aUcyl phosphatidylcholine side groups. Biomacromolecules 2006 7(9) 2591-9. 

Zhang X, Tan D, Li J, Tan H, Fu Q. Synthesis and hemocompatibity evaluation of segmented polyurethane end-capped with both a fluorine tail and phosphatidylcholine polar head groups. Biofouhng 2011 27(8) 919—30. 

Marie-Pierre Krafft at the Institut Charles Sadron, Strasbourg, has studied the polymerization of hydrophobic monomers such as isodecylacrylate (ISODAC) in small rmil-amellar vesicles of perfluoroalkylated phosphatidylcholine (F-PC). The process was compared with that for polymerization of ISODAC in egg PC vesicles. In the case of F-PC vesicles the formed pol3mer was homogeneously distributed throughout the vesicles whereas for egg-PC, parachute polymerization was found to be operative. Ferro and Krafft have also studied the effect of addition of semi-fluorinated alkanes (C jH2 j+iC F2 +i, H jF ) such as HioFe on Ca -induced fusion and the rate of release of 5,6-carboxyfluorescein referred to as (CF) from the water cores of the vesicles. For HioFg, the rate of fusion was reduced by an order of magnitude, and there was a 40-fold decrease in the rate of release of CF, as compared with phosphatidylserine vesicles as a reference. 

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