Fluorinated HPLC solid phases

Eor the separation of alkaloids prior to MS analysis, perfluorinated stationary phases for HPLC columns can be a useful alternative to the reversed phase, alkyl-bonded silica-based stationary phases such as the C8 and C18 reversed phase columns [10]. 

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The synthesis reported by Hamacher et al. has been routinely used to prepare [ F]FDG in PET production centers around the world. The synthesis requires no HPLC purification, and the described RCY was excellent (>90%, EOB). As noted above, [ F]FDG is the most widely used fluorine-18-labeled radiopharmaceutical to date, and so the synthesis has also been adapted for solid phase. SPOR strategies for preparation of [ F]FDG, shown in Scheme 13.3, have beenreportedby Wadsworth etal. and Brady etal. and illustrate proof-of-concept. Notably, these authors used a concept based on perfluorosulfonate linker units to attach the precursor to the resin. The cleavage step used standard radiofluorination... 

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