Fluorides, biologically significant

This technique has been applied to the synthesis of fluormated dopamine and other compounds of biological significance Fluoroheterocycles such as fluoro-imidazoles [JJ, 36] and fluoropyrazoles [37] can also be prepared by the photo Balz-Schiemann technique (equation 9) Photochemically induced in situ fluoro dediazoniation can also be applied to arenediazonium fluorides in hydrogen fluo nde-pyndine media Thus, o-fluoroanisole is obtained in 73% yield at 20 °C after I8h [dS]... 

MacNicol and Robertson [37] have cautioned that perfluorochemicals cannot be assumed to be inert in biological systems. Kissa and Kinney [29] found, however, that the presence of fluorinated surfactant-related organic fluorine in blood does not affect the inorganic fluoride concentration significantly (Table... 

Radi et al. (2013) carried out the synthesis of 1,4-disubstituted pyrazolo[3,4-d] pyrimidines with allopurinol, tetra-n-butylammonium fluoride (TBAF) mediated by N1-functionalization, which was followed by C4 nucleophihc substitution under microwave-assisted heating. These derivatives have biological significance. 

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