Fluoride-resistant variant

Sudo et ul 1996 Mackawa et at.. 1997). Sudo et at. describe a fluoride-resistant variant that appears to be unique to the Japanese, whereas the polymorphisms producing this phenotype (FI and F2) in North American and European populations are apparently absent. 

The second so-called fluoride-resistant variant is similarly differentiated from the normal and dibucaine-resistant enzymes by its different sensitivity to the pseudocholinesterase inhibitor NaF. 

The frequency distribution of the allele for the dibucaine-resistant enzyme variant can be seen from Table 2. The expected frequency of homozygotes for the variant in European and North American populations is 1 2000-3000. The frequency of the fluoride-resistant variant has not been tested but it seems to be... 

W7. Whittaker, M., The pseudocholinesterase variants. A study of fourteen families selected via the fluoride resistant phenotype. Acta Genet. (Basel) 17, 1-12 (1967). 

Immunological examination of the atypical enzyme showed that it is produced in normal amounts but is functionally impaired — it is a qualitative variant (Ecker.son et al., 1983). It appeared that the fluoride-resistant enzyme is also a qualitative variant (see Section 1I.C.4). 

L32. Liddell, J., Lehmann, H., and Davies, D., Harris and Whittaker s pseudocholinesterase variant with increased resistance to fluoride. A study of four families and the identification of the homozygote. Acta Genet. (Basel) 13, 95-108 (1963). 

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