Fluoride -resistant acid phosphatase

Nagy JI, Hunt SP (1982) Fluoride-resistant acid phosphatase-containing neurones in dorsal root ganglia are separate from those containing substance P or somatostatin. Neuroscience 7 89-97... 

KnyihAr, E., 1971, Fluoride-resistant acid phosphatase system of nociceptive dorsal root afferents, Experientia 27 1205-1207. 

KnyihAr, E., Laszlo, I., and Tornyos, S., 1974, Fine structure and fluoride-resistant acid phosphatase activity of electron-dense sinusoid terminals in the substantia gelatinosa Rolandi of the rat after dorsal root transection, Exp. Brain Res. 19 529-544. 

Since disturbed acid phosphatase activity has been associated with pathological conditions, the research has focused on the development of diagnostic methods for detection of activity as a marker for the onset of the disease, and in some extent to the development of inhibitors rather than activators to treat those conditions in which the increase in enzyme activity has a direct effect on the evolution of the disease. In particular, only the development of bisphospho-nate derivatives as inhibitors for tartrate-resistant acid phosphatase found their way to the market for treatment of osteoporosis [41], Typical inhibition of phosphatase activity includes anionic species such as L-(+)-tartrate, phosphate, vanadate, molybdate, and fluoride and neutral molecules such as formaldehyde. Vanadate ion,, is a competitive unspecific inhibitor for acid phosphatases by forming transition state analogs. Other oxoanions such as molybdate and tungstate also show inhibitory effects on... 

Jancs6, G., and KnyihAr, E., 1975, Functional linkage between nociception and fluoride-resistant and acid phosphatase activity in the Rolando substance, Neurohiol. 5 42-43. 

---