9-fluorenylmethoxycarbonyl glycopeptide synthesis based

In this chapter we will summarize chemical methods for the stereoselective attachment of carbohydrates to amino acids, with particular emphasis on the preparation of building blocks for use in solid-phase glycopeptide synthesis based on the 9-fluorenylmethoxycarbonyl (Fmoc) protective group strategy. 

A major progress in glycopeptide synthesis was achieved when it was demonstrated that the NHj-terminal 9-fluorenylmethoxycarbonyl (Fmoc) group can be selectively removed from glycopeptides using the weak base morpholine (pK 8.3). This holds true for 0-glycosyl serine and threonine esters, which are sensitive to base-catalyzed -elimination of the carbohydrate [10]. 

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