Foods Flunitrazepam

Food can delay and reduce the hypnotic effects of flunitrazepam and loprazolam. Food can markedly enhance the absorption of quazepam. 

A study in 2 groups of 8 healthy subjects found that when they took single 2-mg doses of flunitrazepam or loprazolam 2 hours after an evening meal (spaghetti, meat, salad, an apple and wine) and 1 hour before going to bed, the peak plasma levels of flunitrazepam and loprazolam were reduced by 63% and 41%, respectively. The time to reach these levels were delayed by 2.5 hours and 3.6 hours, respectively, and the absorption half-lives of the drugs were considerably prolonged. It seems probable therefore that the onset of sleep with these benzodiazepines may be delayed by food. 

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