Fluconazole allergy

Itraconazole and ketoconazole (200-800 mg/day orally for 1 year) are effective in 74% to 86% of cases, but relapses are common fluconazole 200-400 mg daily is less effective (64%) than ketoconazole or itraconazole, and relapses are seen in 29% of responders Severe disease Amphotericin B 0.7 mg/kg/day for a minimum total dose of 35 mj kg is effective in 59% to 100% of cases and should be used in patients who require hospitalization or are unable to take itraconazole because of drug interactions, allergies, failure to absorb drug or failure to improve clinically after a minimum of 12 weeks of itiaconazole therapy... 

Craig TJ, Peralta F, Boggavarapu J. Desensitization for fluconazole hypersensitivity. J Allergy Clin Immunol I996 98(4) 845-6. 

Immunologic In a case of allergy to fluconazole there was no cross-reactivity with voriconazole [59 ]. 

Nakai N, Katoh N. Fixed drug eruption caused by fluconazole a case report and mini-review of the literature. AUergol Int 2013 62(1) 139-41. Rankin BT, Jariwala S. Graded challenge protocol for fluconazole hypersensitivity in a patient with cryptococcal pneumonitis. Ann Allergy Asthma Immunol 2012 108(6) 466. 

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