Flow Strecker reaction

Fig. 4 The microreactor assembly for the Strecker reaction conducted under continuous flow [48, 53]...

Employing a staked plate microreactor (channel dimensions = 100 pm, total volume = 2 ml), Acke and Stevens (2007) reported the continuous flow synthesis of a series of chromenones via a multicomponent route consisting of a sequential Strecker reaction-intramolecular nucleophilic addition and tautomerization, as depicted in Scheme 2. 

Table 18 Comparison of PS-RuCl3133 and PS-Sc(OTf)2 135 catalysts toward the Strecker reaction, conducted under continuous flow...

Strecker reaction A robust heterogeneous self-supported chiral titanium cluster (SCTC) catalyst applied both in batch and continuous mode [44] enabled imine cyanation as well as a three-component Strecker reaction using the corresponding aldehydes and amines under continuous flow conditions in a PBR giving aminonitriles enantiomeric excess values of up to 98%. 

Scheme 7.28 Flow asymmetric Strecker reaction with a single reactor and successive reactors.

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