Flow Rate and Principle of Ion Formation

Let me open this section with a short remark on the term sensitivity. In the first instance, sensitivity is defined as the slope of the response function that describes the signal change depending on a change in analyte amount or concentration. The slope, also known as response factor, always has a physical 

APCI seems to be a very suitable interface principle, particularly for fast UHPLC-MS separations. It should also be mentioned that APCI is less prone to matrix effects in many apphcations, thus having the tendency of being more 

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