Flow protocols

Before attempting to use either type of flow protocol, the appropriate geometry must be selected and the sample must be loaded into the device. There are certain guidelines that should be followed when selecting a geometry and when setting conditions for sample loading. 

Scheme 74 Continuous flow protocol employed for the synthesis of the natural product grossamide (260) using a series of solid-supported reagents, catalysts and scavengers.

FIGURE 12.3 Schematic flow protocol used to create the elongated fibrils. 

To create a blend with a droplet matrix morphology, a prerequisite to form the elongated fibrils during the flow protocol, 1% emulsions of the caseinate-rieh phase in the alginate-rieh phase have been used. The low concentrations of the dispersed phase are ehosen to provide suflBeient transparency necessary to perform the optieal measurements. 

Experimental protocols are amenable to change by using micro-flow conditions. 

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