Flow in Channels with 3D Elements

Fabrication of 3D Microfluidic Strucmres - Flow in Channels with 3D Elements... 

As an application, the flow in rough microchannels was applied theoretically in the nucleic acid extraction process [8], which is the first critical step for many nucleic acid probe assays. Using a microchannel with 3D prismatic elements on the channel wall can dramatically increase the surface area-to-volume ratio and hence enhance the nuclei acid adsorption on the wall. The opportunity for molecule adsorption is also increased due to the induced pressure resisting the central bulk electroosmotic flow. It is found that decreasing the electroosmotic flow velocity or the channel height enhances nuclei adsorption. 

D flows and time-dependent 2D flows, and mixes the fluid by continuously stretching different volumes of the fluid and folding them into one another. In a qualitative sense, the path taken by a given fluid element in the flow depends in a sensitive way on its encounters with a series of weak secondary flows or eddies, present even at low Re in the comers of channels, which transport the element across the flow [167],... 

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