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QXP/FLO

Key words Drug targets, Hot spots, Druggability, Flo-QXP, Pocket finder, Structure superimposition, Target promiscuity, Protein cavity... [Pg.141]

Fig. 2. QSURF protein surface from FLO-QXP around ligand in the hinge region of the ATP binding site of a kinase. The scaffold makes two hydrogen bonds with the protein backbone (hinge). The micro-cavity on the right of the iigand dot circle) is created by three atoms in the vicinity, the iines of singuiarity in the moiecuiar surface resuits of the intersection between two protein atoms. The three color code of the protein surface corresponds to the hydrophobic area (yelloWi or negative and positive polar areas (Woe and red, respectively). Fig. 2. QSURF protein surface from FLO-QXP around ligand in the hinge region of the ATP binding site of a kinase. The scaffold makes two hydrogen bonds with the protein backbone (hinge). The micro-cavity on the right of the iigand dot circle) is created by three atoms in the vicinity, the iines of singuiarity in the moiecuiar surface resuits of the intersection between two protein atoms. The three color code of the protein surface corresponds to the hydrophobic area (yelloWi or negative and positive polar areas (Woe and red, respectively).
See other pages where QXP/FLO is mentioned: [Pg.149]    [Pg.150]    [Pg.153]    [Pg.159]    [Pg.160]    [Pg.160]    [Pg.149]    [Pg.150]    [Pg.153]    [Pg.159]    [Pg.160]    [Pg.160]    [Pg.277]    [Pg.498]   
See also in sourсe #XX -- [ Pg.149 , Pg.150 , Pg.153 , Pg.159 , Pg.160 ]



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