Flecainide pharmacological effects

Pharmacology Flecainide has local anesthetic activity and belongs to the membrane stabilizing (Class I) group of antiarrhythmic agents it has electrophysiologic effects... 

These are class IC drugs with similar pharmacological profiles and with the same indication range and adverse effects. They are mainly used for the treatment of severe, lifethreatening ventricular tachyarrhythmias, and non-sustained ventricular tachycardia or high-frequency premature ventricular beats. The main adverse effects are cardiovascular, including proarrhythmic actions and severe negative inotropic effects, especially in patients with impaired cardiac function. Both flecainide and encainide increase the risk of sudden death in patients with myocardial infarction and asymptomatic unsustained ventricular arrhythmias. 

Flecainide is a class Ic antidysrhythmic drug. Its clinical pharmacology, clinical use, and adverse effects have been reviewed (1-3). 

Encainide (Enkaid) (Fig. 26.13) represents another benzamide derivative, with similar pharmacological properties to flecainide but with less negative inotropio effect. 

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