Parecoxib Flecainide

FLECAINIDE NS AIDS Parecoxib may t flecainide levels Parecoxib weakly inhibits CYP2D6-mediated metabolism of flecainide Monitor PR and BP closely. If possible, use only short courses of NSAID... 

As parecoxib is rapidly metabolised to valdecoxib, the interactions are usually considered to be due to the effects of valdecoxib. The manufacturer of parecoxib cautions the concurrent use with carbamazepine, dexamethasone and rifampicin as their effects on parecoxib have not been studied. Valdecoxib increases the levels of dextromethorphan and omeprazole. Because of these interactions, caution is advised with drugs that are metabolised by the same isoenzymes, nameiy flecainide, metoprolol, propafenone, omeprazoie, diazepam, imipramine and phenytoin. No interaction appears to occur between parecoxib and midazolam. 

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See also in sourсe #XX -- [ ]

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