Flagellins

Proteins can be broadly classified into fibrous and globular. Many fibrous proteins serve a stmctural role (11). CC-Keratin has been described. Fibroin, the primary protein in silk, has -sheets packed one on top of another. CoUagen, found in connective tissue, has a triple-hehcal stmcture. Other fibrous proteins have a motile function. Skeletal muscle fibers are made up of thick filaments consisting of the protein myosin, and thin filaments consisting of actin, troponin, and tropomyosin. Muscle contraction is achieved when these filaments sHde past each other. Microtubules and flagellin are proteins responsible for the motion of ciUa and bacterial dageUa. 

Peptides formed during tryptic digest of Salmonella flagellin were immobilized on the WPG-PG to prepare immunoadsorbents for the isolation of monoreceptor antibodies from rabbit serum against H-antigens of Salmonella spp. [129]. The... 

C. Winstanley and J. A. W. Morgan, The bacterial flagellin gene as a biomarker for detection, population genetics and epidemiological analysis. Microhiolof y 143 . 3071 (1997). 

FliC = Flagellin sequence in EAggEC responsible for IL-8 induction [64]. ... 

Hawn, T.R., et al., A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires disease, J. Exp. Med. 198, 10, 1563, 2003. 

Kuwajima, G., Kawagishi, I., Homma, M., Asaka, J.-I., Kondon, E., and Macnab, R. (1989). Export of an N-terminal fragment of Escherichia coli flagellin by a flagellum-specific pathway. Proc. Natl. Acad. Sd. U.S.A. 86, 4953—4957. 

Flagellin (TLR5 ligand) Increase Treg-suppressive activity Increase FoxP3 expression in Treg... 

Natronobacterium magadii (haloalkaliphilic archaeon, enzyme binds specifically to natronobacterial flagellins [38]) [38]... 

The switch is accomplished by periodic inversion of a segment of DNA containing the promoter for a flagellin gene. The inversion is a site-specific recombination reaction (see Fig. 25-39) mediated by the Hin re-combinase at specific 14 bp sequences (hix sequences)... 

Hin recombinase FljB flagellin FljA protein (repressor) ... 

Phase variation (Salmonella) Hin/hix Site-specific Alternative expression of two flagellin genes allows evasion of host immune response. 

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