FKBP rapamycin-associated protein

In 1994 two groups independently and concurrently reported the identification of a protein which interacted with FKBP 12 only in the presence of rapamycin. One of these groups was Schreiber s, who isolated the human protein and named it FRAP, for FKBP and rapamycin associated protein.33 The other group, led by Solomon Snyder at Johns Hopkins, isolated a similar protein from rat brain extracts. They named this protein RAFT, for rapamycin and FKBP target.34 Sequencing demonstrated that these were the mammalian homologues of the yeast TOR proteins. 

Partaledis, J. A., Fleming, M. A., Harding, M. W., and Berlin, V. (1992). Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/ rapamycin binding protein. Yeast 8, 673-680. 

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