Five-, Six-, Seven-, and Eight-Component Reactions Based on the Ugi Reaction

4 FIVE-, SIX-, SEVEN-, AND EIGHT-COMPONENT REACTIONS BASED ON THE UGI REACTION 

Although less explored, five-component reactions represent an interesting manner to obtain highly functionalized scaffolds, but only few examples have appeared after the pioneering work reported by Armstrong in 1998 [54]. The 

SCHEME 7.20 Sequential five-component synthesis of diamides 47 from oiganolithium or Grignard compounds. 

SCHEME 7.22 Access to chiral lactams 55 via Friedel-Crafts and Ugi reaction. 

---