Fittig synthesis Perkin transformation

Related condensations involving the replacement of the anhydride component with succinic acid (Fit-tig synthesis) or with malonic acid (Knoevenagel condensation, see Volume 2, Qiapter 1.11) provide complementary preparative methods which are useful for both aromatic and aliphatic systems. The Fittig extension of the Perkin transformation involves heating an aliphatic or aromatic aldehyde with sodium succinate and acetic anhydride to give the condensation products (17), which lose carbon dioxide to afford p,7-unsaturated cartoxylic acids (18), accompanied by small amounts of the corresponding 7-buty-rolactones (19 Scheme 7)P... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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