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Fisher oxazole synthesis

The Fisher oxazole synthesis involves condensation of equimolar amounts of aldehyde cyanohydrins (1) and aromatic aldehydes in dry ether in the presence of dry hydrochloric acid. ... [Pg.234]

Brooks, D. A. Fisher Oxazole Synthesis in Name Reactions in Heterocyclic Chemistry, Li, J. J. Corey, E. J., Eds. Wiley Sons Hoboken, NJ, 2005, 234-236. (Review). [Pg.236]

The condensation of an aromatic aldehyde with an aldehyde cyanohydrin under anhydrous acidic conditions provides oxazoles. The convergent synthesis couples the C2 substituent contained in the aromatic aldehyde and the C5 substituent in the cyanohydrin (C4 must necessarily remain unsubstituted). Through a modified procedure, Onaka prepared the alkaloid halfordinol in one step, utilizing the Fisher oxazole synthesis. [Pg.237]

Onaka demonstrated the utility of a modified Fisher method in the one-step synthesis of oxazole alkaloid Halfordinol (16) in higher overall yield than previously reported by Robinson-Gabriel synthesis. ... [Pg.236]

See other pages where Fisher oxazole synthesis is mentioned: [Pg.234]    [Pg.237]    [Pg.237]    [Pg.230]    [Pg.256]    [Pg.230]    [Pg.234]    [Pg.237]    [Pg.237]    [Pg.230]    [Pg.256]    [Pg.230]    [Pg.229]   
See also in sourсe #XX -- [ Pg.234 , Pg.235 ]

See also in sourсe #XX -- [ Pg.237 ]



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