First-generation typical

2 First-generation ( typical ) antipsychotic drugs - haloperidol and others 

Drugs that can increase the serum levels/effects of haloperidol/ miscellaneous 

Drugs whose therapeutic effects were shown to be opposed by haloperidol/ miscellaneous 

Drugs whose serum levels/effects can be Increased by haloperidol/ miscellaneous 

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TABLE 34-6. First-Generation (Typical) Antipsychotic Dosing of Decanoate Preparations... 

TABLE 34-7. Side Effects of First-Generation (Typical) Antipsychotics... 

Tricyclic antidepressant A family of first-generation (typical) antidepressants with a three-ringed structure that inhibit the action of monoamine transporters. 

First-generation (typical) antipsychotics include amisulpride, chlorpromazine, fluphenazine, haloperidol, promethazine, promazine, trifluoperazine... 

Current antipsychotics used to treat patients are divided into two classes the first generation antipsychotics (FGA) or typicals (e.g., chlorproma-zine, haloperidol, thioridazine, and loxapine) and the second generation antipsychotics (SGA) or atypicals (i.e., clozapine, olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone, and asenapine). 

A first generation poly(amido amine) dendrimer has been functionalized with three calyx[4]arenes, each carrying a pyrene fluorophore (4) [30]. In acetonitrile solution the emission spectrum shows both the monomer and the excimer emission band, typical of the pyrene chromophore. Upon addition of Al3+ as perchlorate salt, a decrease in the excimer emission and a consequent revival of the monomer emission is observed. This can be interpreted as a change in the dendrimer structure and flexibility upon metal ion complexation that inhibits close proximity of pyrenyl units, thus decreasing the excimer formation probability. 1H NMR studies of dendrimer 4 revealed marked differences upon Al3+ addition only in the chemical shifts of the CH2 protons linked to the central amine group, demonstrating that the metal ion is coordinated by the dendrimer core. MALDI-TOF experiments gave evidence of a 1 1 complex. Similar results have been obtained for In3+, while other cations such as Ag+, Cd2+, and Zn2+ do not affect the luminescence properties of... 

Hydroquinone oxidation to quinone occurs via two linked one-electron transfer stages. The first step (typically metal catalysed) yields the semiquinone radical intermediate, which is resonance stabilised. The second step involves electron transfer to molecular oxygen to generate superoxide and quinone [70]. This reaction mechanism is common to all hydroquinones, catechols, resorcinols, and so forth. 

The first generation NLO polymers were side chain polymers, usually made by copolymerisation of a monomer bearing the chromophore bridged by a flexible spacer group with a co-monomer, commonly methacrylates. This is a flexible process allowing a wide range of co-polymers to be made. A typical example of this type of polymer is the methyl methacrylate azo dye co-polymer (5.9). 

Fig. 5 Typical room temperature TOF hole transient for a first generation bis-fluorene dendrimer film of thickness 300 nm and an electric field of 1.6 x lO V/cm. Also shown is the structure of the dendrimer. From [49] with permission. Copyright (2008) by Elsevier...

Tetracyclines have been marketed since 1984, and, since discovery, some first-generation tetracyclines such as tetracycline, oxytetracycline, and chlorotetracychne have been extensively used in livestock and aquaculture, besides clinical use by humans. For human use, the second-generation tetracyclines doxycycline and minocycline have been prescribed to a great extent, and indeed prescription of the latter has steadily increased in the United States over the 2003-2005 period (Fig. 1.7). However, each of these tetracyclines is less than 0.5% of all the other 200 most prescribed dmgs. Tetracyclines are also prescribed to a good extent in several European countries (Fig. 1.6), with the exception of Italy and Denmark where per capita prescriptions are quite minimal, that is, <25 prescriptions per 1000 inhabitants (Molstad et ah, 2000). They are also widely used in animal husbandry where daily therapeutic doses of 40 mg tetracycline kg liveweight are typical (Kilhne et al., 2000). 

Phosphoric acid fuel cells (PAFC) use liquid phosphoric acid as an electrolyte - the acid is contained in a Teflon-bonded silicon carbide matrix - and porous carbon electrodes containing a platinum catalyst. The PAFC is considered the "first generation" of modern fuel cells. It is one of the most mature cell types, the first to be used commercially, and features the most proven track record in terms of commercial applications with over 200 units currently in use. This type of fuel cell is typically used for stationary power generation, but some PAFCs have been used to power large vehicles such as city buses. 

Chloroaluminate ILs, the first-generation ILs, consist of a mixture of an -onium chloride (typically, of course, imidazolium or ammonium) and varying proportions of aluminum frichloride (AICI3). (The sfrucfures of all cations and anions that are discussed in this chapter are depicted in Figure 13.1.)... 

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