First Generation Syntheses of Epothilones A and

The first part of this report includes a comprehensive account of our efforts and successes in this regard. In fire latter discourse, we shall diverge to report our findings regarding the biological activity of these remarkable compounds and their potential usefulness in a clinical setting. 

Although the epothilones are structurally less complex that the taxanes, we foresaw several synthetic issues concerning this venture that would require careful attention. The structures of the epothilones invite retrosynthetic dissection into two regions. The polypropionate domain of the epothilones constitutes carbons C1-C8, while the 

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