First example monocrystalline particles of paracetamol

In this first example, paracetamol was recrystallized separately in three different types of solvents (ethanol, water and dioxane) with different boiling points, molecular weights, dielectric constants and paracetamol solubilising power. After the crystallization process, crystals were separated by filtration under vacuum and washed with the same crystallization solvent. Each batch was divided into four fractions to be dried differently. 

The paracetamol crystals were submitted to four different drying conditions (Table 15.2.3.2)  

Very moderate under ventilated hood at 20°C for 24 hours and then in a ventilated oven at 35°C for 48 hours. 

Dried erystals were observed by optical and scanning electron microscopy (SEM) in order to measure their Ferret mean diameter and to determine their habit and texture. The mean diameters of erystals obtained from different solvents and submitted to different drying conditions are reported in Table 15.2.3.3. 

Type of particles Drugs Type of drying Temperature Time 

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