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Finding Binding Pockets

To probe whether the binding pocket exerts an effect on the stability of the complexes, a series of diamagnetic zinc complexes [Zn2(L19)(02CR)] + 49a-f bearing different carboxylate coligands was prepared and analyzed by NMR spectroscopy in the solution state (Table III). The most important findings of these investigations are as follows ... [Pg.445]

These conclusions are still consistent with the finding that significant conformational differences between Pr and Pfr do in fact exist ([65,147] for reviews see [8c, 148]). They can be rationalized—albeit not with conclusive rigour—by a conformational adaptation of the apoprotein part located around the bilatriene-binding pocket, following the Z E photoisomerization of the chromophore. This local change then should suffice to determine through bilatriene chromophore-protein interactions the spectroscopic characteristics of the chromophore as well as stability and reactivity of the two photochromic forms of phytochrome. [Pg.267]

Figure 13.2 features the currently practiced paradigm of structure-based drug design (Dixon, 1992). The key step, besides finding an inhibitory compound, is the elucidation of the 3D structure of the complex between the binding pocket and inhibitor. [Pg.376]

These assumptions are further supported by the finding that mutations that are believed to alter the geometry of the binding pocket or the conformational changes... [Pg.302]


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Binding pocket

Fragments to Find Hot Spots in Binding Pockets

POCKET

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