Filling additional pockets

A useful characterization of these modified lignocellulosic materials would be that of the size or of the size distribution of the water-filled submicroscopic pockets and of the additional internal surface area in the water-swollen condition created by the various modifications. Characterization such as this based on adsorption measurements has been made by Stone and Scallon (34). Additional characterizations based on x-ray-scattering measurements are being carried out at the U. S. Forest Products Laboratory. 

In an effort to identify more potent inhibitors of HIV PR, a series of compounds was synthesized in which another enzyme pocket could be filled in addition to the four inner pockets occupied by the previously described compounds. This strategy is similar to the one adopted by Upjohn researchers.32"46 Molecular modeling studies indicated substitution at the 4 -position of the 3-S-(2-te/ -butyl-5-methyl) phenyl moiety... 

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