Fiesselman thiophene synthesis

The classic example of a Fiesselman thiophene synthesis is the reaction involving a methylthioglycolate and an a,p-acetylenic ester in the presence of a base. 

An interesting example of the Fiesselman thiophene synthesis was reported during the investigation of the susceptibility of golfomycin A toward nucleophilic attack. Treatment of TBS-protected golfomycin A with methyl thioglycolate in the presence of base produced the strained thiophene product in 20% yield. ... 

The Fiesselmaim thiophene synthesis has also been used to produce various 2,3-diarylthiophenes to investigate their potential anti-inflammatory properties. The thiophene intermediate synthesized via the Fiesselman... 

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