Fibrates contraindications

REPAGLINIDE FIBRATES-GEMFIBROZIL Nearly eightfold t in repaglinide levels. Risk of severe and prolonged hypoglycaemia Hepatic metabolism inhibited The European Agency for the Evaluation of Medicinal products contraindicated concurrent use in 2003. Bezafibrate and fenofibrate are suitable alternatives if a fibric acid derivative is required... 

Renal failure is a relative contraindication to the use of fibric acid agents, as is hepatic dysfunction. Combined statin-fibrate therapy should be avoided in patients with compromised renal function. Gemfibrozil should be used with caution and at a reduced dosage to treat the hyperlipidemia of renal failure. Fibrates should not be used by children or pregnant women. 

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