Fetuin structural analysis

The 0-glycosically linked carbohydrate chains of fetuin have been cleaved from the protein by alkaline borohydride treatment. Structural analysis revealed the existence of tri- and tetra-saccharides linked 0-glycosidically to L-serine or L-threonine and having structures identical to those previously identified for bovine K-casein and human chorionic gonadotrophin [(27) and (28)]. The A-glycosidically linked chains of fetuin have been assigned structures (36) %r (37). ... [Pg.396]

The strategy used to perform the PMP oligosaccharide profile analysis, with the use of bovine fetuin as a model system, is given in Scheme 1. Bovine fetuin, a major glycoprotein in fetal calf serum, has been widely used as a model for the study of glycoprotein structure. This glycoprotein contains both N- and O-linked oligosaccharides and detailed structural information is available (9-11). [Pg.323]

Hydrazinolysis, deamination, and methylation analysis have demonstrated that ai-acid glycoprotein, fetuin, lactotransferrin, and transferrin possess structural features in common. ... [Pg.322]

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