Fetotoxicity dose-response information

Developmental Toxicity. Evidence indicates that NDMA is fetotoxic to rats and mice, but NOAELs have not been defined. Well-conducted developmental studies using several exposure levels and environmentally relevant routes of exposure could provide the dose-response information necessary to determine the threshold for fetotoxicity and to determine the possible relevance and risk for humans. Additional studies also could determine if NDMA is a transplacental carcinogen. 

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