Sparfloxacin Ferrous sulfate

Kanemitsu K, Hori S, Yanagawa A, Shimada J. Effect of ferrous sulfate on the absorption of sparfloxacin in healthy volunteers and rats. Drugs 1995 49(Suppl 2) 352-6. 

Ferrous fumarate, gluconate, sulfate and other iron compounds can reduce the absorption of ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin and sparfloxacin from the gut. Serum levels of the antibacterial may become sub-therapeutic as a result. Limited evidence suggests that fleroxacin is not affected and lomefloxacin is only minimally affected. Glemi-floxacin does not appear to interact when given 2 hours before or 3 hours after ferrous sulfate. No interaction appears to occur with iron-ovotransferrin. Zinc appears to interact like iron. 

In a single dose study in 6 subjects, 525 mg of ferrous sulfate (equivalent to 170 mg of elemental iron) reduced the AUC of sparfloxacin 200 mg by... 

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See also in sourсe #XX -- [ ]

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