Ferrocenyl carbodiimides

Likewise, cyclization to give 2-arylamino-3-ferrocenecarbonyl quinolines 59 occurs in the generation of the ferrocenyl carbodiimide 58. ... 

Carbodiimides are widely used to mediate the attachment of biomarkers to polypeptides. Examples include carbodiimides with ferrocenyl substituents. Also, peptides are covalently modified with ferrocenecarboxylic acid using EDCCl and N-hydroxy-succinimide to promote the coupling to surface lysines. They also mediate the attachment of substituents to single walled nanotubes (SWNTs) and multiwalled nanotubes (MWNTs). Also, microdots are attached to virus molecules using a water soluble carbodiimide. The attachment of viral DNA to gold particles is used in the manufacture of a new type of vaccine. 

Ferrocenyl substituted unsaturated carbodiimides 56, generated in situ, undergo intramolecular cyclization to give heterocyclic substituted ferrocenyl derivatives 57. ... 

Quinazolines have also been prepared by the reaction of a polystyrene-bound phosphoranimine and isocyanates, followed by an intramolecular cyclization of the carbodiimide intermediate 4-Ferrocenylidene-l-aminoimidazolone derivatives have been obtained from p-ferrocenyl-a-azidoacrylates and isocyanates followed by condensation of the resulting carbodiimidoester with hydrazines " In a Staudinger/ aza-Wittig process and in the presence of PPh3, bimetallic ferrocenyl oxazole derivatives (23) - (26) have been formed by the reaction of a-... 

An alternative route to Fc-peptides, developed by Beck and coworkers, uses ferrocenyl oxazolones, which can be obtained by the reaction of Fc-amino acids (19) with a carbodiimide (Scheme 5). The resulting oxazolone (20) undergoes a nucleophilic ring-opening reaction with the amino group of a C-protected amino acid to give the desired Fc-peptide (4). 

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