Ferrocenoyl amino acids synthesis

Scheme 12.1 Synthesis of ferrocenoyl amino acid esters (4) via the acid chloride and active ester methods (i) PCI5 or SOCI2 (ii) carbodiimide such as DCC (N Ji -dicy clohexy lcarbodiimide) or EDC (1 -ethyl-3-(3-dimethyl-aminopropyl)carbodiimide), HOBt (1-hydroxybenzotriazole) (iii) and (iv) peptide or amino acid and base.

Scheme 1 Synthesis of ferrocenoyl amino acid esters (3) and peptides (4) via the acid chloride method.

Scheme 5 Synthesis of ferrocenoyl peptides (4) via the ferrocenyl oxazolone (20) starting from a ferrocenoyl amino acid (19) (a) DCC or EDC, (b) amino acid.

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See also in sourсe #XX -- [ , , ]

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