Ferrocenes BPPFA ligands

One of the branches in ligand design was provided by Kumada and his introduction of the ferrocene backbone for BPPFA [99-101] (20a) and BPPOH [102] (20b). This development leads us to the next class of ligands - ferrocene-based. Other variations for development include changes in the backbone and incorporation of the phosphorus into a phospholane (see Section 23.6). 

Ferrocene-based complexes have some potential for the enantioselective reduction of ketones, but compared to other ligand classes this is relatively limited [3]. Rh complexes of bppfa, bophoz and josiphos are among the most selective catalysts for the hydrogenation of a-functionalized ketones (Table 25.9 Fig. 25.18, 30-32). Ru complexes of walphos and ferrotane are quite effective for... 

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