1,1’-Ferrocene dimethanol

During the synthesis of 1,1 ferrocene dimethanol from ferrocene, the starting material, ferrocene and the intermediates, 1,1 -diacetyl-ferrocene and dimethyl 1,1 -ferrocene dicarboxylate all occur in the product, and chromatograms of this mixture are shown in Figure 234. 

The aptamer described above was attached to the surface of the silica colloidal crystal comprising 290 nm silica spheres (resulting in 22.5 nm radius nanopores) via maleimide-activated support. The transport rate of a redox-active probe molecule (ferrocene dimethanol) through the resulting nanoporous films was measured as a function of cocaine concentration using cyclic voltammetry. A neutral redox probe, Fc(CH20H)2, was used to exclude the possibility that the observed changes in the molecular transport would result from electrostatic effects [26,27]. 

Ferrocene-1,1,-dimethanol [ 1291-48-1 ] M 246.1, m 107-108°. Obtained from the diacid with LiAlH4 reduction and recrystd from Et20-pet ether. [J Am Chem Soc 82 4111 7960.]... 

In addition to stereoselective metalation, other methods have been applied for the synthesis of enantiomerically pure planar chiral compounds. Many racemic planar chiral amines and acids can be resolved by both classical and chromatographic techniques (see Sect. 4.3.1.1 for references on resolution procedures). Some enzymes have the remarkable ability to differentiate planar chiral compounds. For example, horse liver alcohol dehydrogenase (HLADH) catalyzes the oxidation of achiral ferrocene-1,2-dimethanol by NAD to (S)-2-hydroxymethyl-ferrocenealdehyde with 86% ee (Fig. 4-2la) and the reduction of ferrocene-1,2-dialdehyde by NADH to (I )-2-hydroxymethyl-ferrocenealdehyde with 94% ee (Fig. 4-2lb) [14]. Fermenting baker s yeast also reduces ferrocene-1,2-dialdehyde to (I )-2-hydroxymethyl-ferro-cenealdehyde [17]. HLADH has been used for a kinetic resolution of 2-methyl-ferrocenemethanol, giving 64% ee in the product, (S)-2-methyl-ferrocenealdehyde... 

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