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Ferrioxamines biomimetic

While in the ferrioxamine biomimetics the aim was to reduce the conformational freedom by shortening the length of the spacers to prevent formation of mer (trans) isomers and favor instead the exclusive formation of the fac (cis) isomers, in preparing coprogen analogs the mer isomers are pursued. [Pg.790]

The only clinically approved and therefore most studied natural siderophore is des-ferrioxamine B (DFO), and hence it serves as a reference compound in evaluating new biomimetic siderophores. The following discussion will include a short description of several natural hydroxamate siderophore families in separate tables, followed by the various attempts to prepare novel simplified structures that reproduce biological activity. These tables are not intended to cover the entire archive of known siderophores, but merely to allow the reader to observe structural variations, their chemical composition and location as well as conserved domains. [Pg.760]

Natural and biomimetic hydroxamic acid based siderophores TABLE 2. Natural ferrioxamines and their structural variations... [Pg.781]

In the ferrioxamine family, two approaches were followed one, based on modifying the amine at the end of the extended tail in the natural ferrioxamine B with an appropriate fluorophore the second, substituting biomimetic analogs 146-155 on either their amino or carboxy termini, to assess their chemical and biological differences. Both approaches were followed and two classes of compounds were prepared with various fluorescent tags. [Pg.797]


See other pages where Ferrioxamines biomimetic is mentioned: [Pg.142]    [Pg.752]    [Pg.755]    [Pg.782]    [Pg.790]    [Pg.799]   
See also in sourсe #XX -- [ Pg.782 , Pg.783 , Pg.784 , Pg.785 , Pg.786 , Pg.787 , Pg.788 , Pg.789 ]




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Ferrioxamines

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