Fenozan antimalarial

Fenestrindane monoalcohol, C-H bond dioxirane oxygen insertion, 1162 Fenozan antimalarial endoperoxide degradation, 1292-3 iron(lV) oxo species, 1292, 1293, 1294, 1309... 

In addition to artemisinin, other synthetic trioxanes and endoperoxides (fenozan BO-7 4 and arteflene 5 " ) have enjoyed some success arteflene reached Phase II pre-clinical trials. More recently, Vennerstrom and coworkers have reported on the outstanding antimalarial properties of several 1,2,4-trioxolanes, one of which, OZ 277 (6), has entered clinical trials in man . These exciting, easily prepared drugs will be discussed in detail later in this chapter. In order to determine the parasiticidal action of this class of antimalarial, many research groups have focused their efforts on artemisinin and its semi-synthetic derivatives (artemether, arteether and artesunate Ic, Id and le), and this is the point where our discussion will begin. 

Jefford and coworkers have investigated the iron(II) degradation of fenozan BO-7 (4) and have proposed that a primary radical must be implicated in the mechanism of action of 1,2,4-trioxane antimalarials . Fenozan was degraded using iron(II) chloride in aqueous... 

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