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Fasting plasma glucose increased

As fasting plasma glucose increases, it is overt that insulin secretion decreases progressively... [Pg.67]

MTP-1403 (91) and MTP-1307 (92) are able to improve glucose tolerance in normal rats and in insulin-resistant mice and lower fasting plasma glucose in rats but not in insulin-deficient diabetic animals. In rats, the hypogly-caemic effect is accompanied by an increase in insulin levels, more pronounced with MTP-1307 than with MTP-1403. The mechanism of action is unknown. In vitro MTP-1307 inhibits gluconeogenesis in hepatocytes and glucose oxidation in adipose tissue, at 0.1 to 3 mM [397]. [Pg.43]

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Fasting glucose

Fasting plasma glucose

Plasma glucose

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