Fast spiking neuron

Fig. 6. Effects of cannabinoids on synaptic transmission in nuclei belonging to the extrapyramidal motor control system. DA, dopamine FSN, fast spiking neuron MSN, medium spiny neuron SNC, substantia nigra pars compacta SNR, substantia nigra pars reticulata. CBi receptor-mediated inhibition of neurotransmission was demonstrated at many synapses of this motor control system. In addition to the proved sites of inhibition, inhibition is very probable at additional sites (based on the localisation of the CBi receptor). For the sake of simplicity, the pathway including the entopeduncular nucleus (globus pallidus medialis/internus) is not shown...

Gerstner W. Population Dynamics of Spiking Neurons Fast Transients, Asynchronous States, and Locking. Neural Compu-tat, 1999, 22 43-89. 

An interesting study was performed on cortical slices (from young adult ferrets) with paired whole-cell recording to study the influence of DA on local inhibitory circuits (Gao et al., 2003). In this investigation, DA was found to depress inhibitory transmission between fast-spiking interneurons and pyramidal neurons, but enhanced inhibition between nonfast-spiking interneurons and pyramidal cells. 

Bennett MV. Seeing is relieving electrical synapses between visualized neurons. Nat Neurosci. 2000 3(l) 7-9. Galarreta M, Hestrin S. A network of fast-spiking cells in the neocortex connected by electrical synapses. Nature. 1999 402(6757) 72-75. 

Spruston In CAl neurons, something analogous happens. If you have a train of spikes that are paired with current injection into the dendrites, you can get Ca spikes. Here, it seems that a crucial role is played by the D type K currents. These D type K" " currents seem to limit the generation of Ca spikes near the soma, and these currents are activated by the action potentials themselves. So if you block either the D-type K currents or the fast Na spikes, this dramatically lowers the threshold for Ca spikes in the soma of CAl pyramidal neurons. It is possible that something similar is happening in the layer 5 neurons (Golding et al... 

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