Fast potential-dependent absorbance

The risk of an adverse systemic reaction following skin contact with a potentially toxic chemical depends on the speed and total amount of absorption through the skin. Several techniques have been devised to measure these parameters across Isolated skin mounted In diffusion cells. The mathematical and kinetic relationships which define the operation of these various systems have been reviewed. A novel kinetic description of the penetration process has been developed and applied to skin absorption measurements for benzoic acid and paraquat. The results suggest that when these substances are deposited on the skin surface In a volatile solvent, a portion of the applied dose Is rapidly solubilized Into the skin and available for fast absorption, while the remainder Is absorbed more slowly. 

Both time-dependent and time-independent quantum theories can be employed to study three-atom, four-atom and polyatomic reactions with respect to nuclei motion. Clever features of the time-dependent wave packet theory are the use of absorbing potentials and the grid basis representations (the fast Fourier transformation and the discrete variable representation). 

---