Farnesyl azide

In another application of coupling proteins to surfaces using click chemistry, Duckworth et al. (2006) carried out prenylation of a protein using a farnesyl azide derivative and the enzyme farnesyl transferase for subsequent chemoselective ligation to alkyne-functionalized agarose beads. The result is a highly discrete, site-specific attachment of the protein to the solid phase at a single location. 

Figure 17.21 An azido-farnesyl diphosphate derivative can be added to cells to obtain farnesylated proteins containing terminal azide groups that can be targeted in a Staudinger ligation reaction. Biotinylation of these post-translationally modified proteins can be done in vivo using a biotin-phosphine derivative.

Labadie, G.R., Wiswanathan, R., and Poulter, CD. (2007). Farnesyl diphosphate analogues with 6-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions. J Org Chem 72 9291-9297. 

Famesol acetate, 415 Farnesyl cyanide, 351, 352 Ferric azide, 153 Ferric chloride, 153-155 Ferric chloride hexahydrato, 111 Ferric chloride-Sodium hydride, 155 Ferric selenocyanate, 155-156 Ferric thiocyanate, 155-156 a-Feirocenylalkylamines, 366 o-F errocenylethanol, 366 Fctizon reagent, 6, 319-320 Finkelstein reaction, 134 Fischer indole synthesis, 284 Flavanoids. 263 Kliivipucino, 43, 44... 

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