Faradaic electrochemistry

The work described above constitutes the beginning of a new area in which the faradaic electrochemistry of discrete, electroactive nanoparticles is explored, both from a... 

The observation of currents attributable to the faradaic electrochemistry of nucleic acids was pioneered by Palecek and coworkers who studied DNA adsorbed on mercury or carbon electrodes [13]. The signals detected by Palecek were attributable to oxidation of the purines, which produced signals indicative of irreversible processes involving adsorbed bases. These reactions were used as a basis for electrochemical analysis of DNA. Kuhr and coworkers later showed that similar strategies could be developed for analysis of nucleic acids via oxidation of sugars at copper electrodes [14-16]. 

Modification of the properties of graphite paste by incorporating ionic charge sites also has been investigated (Lane, unpublished) and may be useful in the near future. At present it can be said that all of the electrodes modified for greater in vivo selectivity are exploratory in nature and results with them must be interpreted with caution. While progress in this direction can be assured, there should be no expectation that a completely specific electrode utilizing faradaic electrochemistry will be developed—for example, one which would differentiate DA from NE. 

Dayton, M.A., Brown, J.C., Stutts, KJ. and Wightman, R.M. (1980) Faradaic electrochemistry at micro-voltammetric electrodes. Analytical Chemistry, 52, 946-950. 

Dayton MA, Brown JC, Stutts KJ, Wightman RM (1980) Faradaic electrochemistry at microvoltammetric electrodes. Anal Chem 52 946-950... 

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