Fanconi syndrome didanosine

A Fanconi syndrome with nephrogenic diabetes insipidus was reported in a patient wifh AIDS who was receiving didanosine (and ofher medications) [115] and also in a patient treated with stavudine and lamivudine [116]. The metabolic acidosis in this case was partly due to lactic acidosis, perhaps related to mitochondrial dysfunction. Abacavir was recently implicated as a... 

Rollot F, Nazal EM, Chauvelot-Moachon L et al. Tenofovir-related fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome the role of lopinavir-rltonavir-didanosine. Clin Infect Dis 2003 37 e174-6. 

Irizarry-Alvarado JM, Dwyer JP, Brumble LM, Alvarez S, Mendez JC. Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus a report of 3 cases. AIDS Read 2009 19 (3) 114-21. 

Tenofovir generally is well tolerated, with few adverse events except for flatulence. Rare episodes of acute renal failure and Fanconi s syndrome have been reported, and the drug should be used with caution in patients with preexisting renal disease. It can increase the AUC of didanosine, and the drugs probably should not be used together. 

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