Familial male precocious puberty

There are a variety of constitutively active mutations in the gene encoding the LH receptor. These variants result in gonadotropin-independent disorders such as testotoxicosis and familial male precocious puberty (FMPP) (91). These disorders are inherited in an autosomal dominant, male-limited pattern (92,93). 

Familial Male Precocious Puberty and Constitutive LH Receptor Mutants... 

The combination of spironolactone (2 mg/kg/day) and testolactone (20 to 40 mg/kg/day) for 6 months or more may be effective for short-term treatment of familial male precocious puberty. 

Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty. Hum Mol Genet 4 183-188... 

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