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Familial Amyotrophic Lateral Sclerosis FALS

Familial amyotrophic lateral sclerosis. Familial amyotrophic lateral sclerosis (FALS) is observed in =10% of all cases, but substantially more ALS cases are suspected to be influenced to some degree by genetic factors [75], Mutations in two genes (SOD1 and ALS2 Table 39-3) have been shown to cause FALS, apart from mutations in tau (MAPT) leading to FTD with parkinsonism and... [Pg.661]

Formation of natural mutants of the corresponding interface residues of human Cu2Zn2SOD in familial amyotrophic lateral sclerosis (FALS) has been demonstrated (18). [Pg.148]

The SDEL algorithm has also been used to study the folding of more complicated systems, such as the wild-type human Cu, Zn superoxide dismu-tase (SOD) dimer. SOD is a 153-residue, homodimeric, antioxidant enzyme that dismutates superoxide ion to hydrogen peroxide and oxygen.It is an eight-strand, flattened, fl-barrel protein with one copper and one zinc ion per monomer.This protein is involved in the familial form of amyotrophic lateral sclerosis (FALS). [Pg.401]

See other pages where Familial Amyotrophic Lateral Sclerosis FALS is mentioned: [Pg.625]    [Pg.318]    [Pg.319]    [Pg.68]    [Pg.154]    [Pg.5796]    [Pg.272]    [Pg.5795]    [Pg.488]    [Pg.25]    [Pg.625]    [Pg.318]    [Pg.319]    [Pg.68]    [Pg.154]    [Pg.5796]    [Pg.272]    [Pg.5795]    [Pg.488]    [Pg.25]    [Pg.736]    [Pg.964]    [Pg.2]    [Pg.2]    [Pg.733]    [Pg.204]    [Pg.377]    [Pg.377]    [Pg.450]    [Pg.349]   


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Familial amyotrophic lateral sclerosis

Lateral sclerosis

Sclerosis

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