Famesyl isothiocyanates

A sesquiterpene isothiocyanate (240) was isolated from the Californian nudibranch Cadlina luteomarginata but was presumed to be concentrated from the Axinella species of sponge which constitutes much of its diet [249]. Famesyl isothiocyanate (241) was isolated from Pseudaxinyssa pitys [250], while theonellin isothiocyanate (242) was isolated from the sponge Theonella cf. swinhoei [251]. 

Two acyclic diterpene tetraene isothiocyanates have been isolated from sponges so far. Famesyl isothiocyanate (220) was obtained from Pseudaxinyssa pitys [184] while compound (+)-221 was isolated from Halichondria sp. [185]. Their structures were elucidated by interpretation of their spectral data. 

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