Facioselectivity, Vectoselectivity and Anguloselectivity at Stereotopic Molecular Faces

The complete description of processes taking place at stereotopic molecular faces involves three fundamental aspects - facioselectivity, vectoselectivity and anguloselectivity. In order to evaluate the interrationships of the underlying three concepts above, we now consider (1,2)-ligogenic processes for all eleven types of molecular stereofaces. 

Consideration of all homotopic faces, with both sets of divalent and trivalent reactants listed above, leads to the following generalizations  

Nonanguloselective (enantioangular arrangements) processes are possible only at faces hl-h3 (found in achiral substrates) there is no nonanguloselectivity on faces h4-h6 (found in chiral substrates). 

All nonanguloselective processes at faces hl-h3 occur with achiral reagents. 

Anguloselective (diastereoangular arrangements) processes can occur on all faces - hl-h6 these encompass achiral as well as chiral substrates. 

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V. Facioselectivity, Vectoselectivity and Anguloselectivity at Stereotopic Molecular Faces... 

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